A Reduced-intensity transplant is a newer type of transplant that follows the same course as conventional transplants, but with less taxing levels of drugs. The transplantation procedure includes the following steps:
Step 1: Pre-transplant Process: Patient has to perform some Pre-transplant tests and procedures before the transplant. It will help the doctor to evaluate the current medical condition of the patient. The process includes:
- Beginning Medical Evaluation
- Conference for Treatment Plan
- Central Venous Catheter Evaluation and Insertion
- Bone Marrow/Stem Cells Harvest: Bone marrow or stem cells required for the transplant are taken from the hip bone or the blood of the donor respectively.
Step 2: Conditioning Process: The conditioning regimen for reduced-intensity uses less chemotherapy and radiation than the standard myeloablative conditioning regimen. Reduced-intensity transplants simply
- Suppress the immune system of the patient enough so that the stem cells injected can engraft and grow.
- It may kill some amount of tumour cells if any
Step 3: Reduce Intensity Transplant: This transplant is a modified version of allogeneic transplantation, where the harvested and processed Bone marrow/Stem cells are transplanted into the body using a central venous catheter. These cells then make their way to the bone marrow space in the body, thereby offering a patient with a tendency to reconstitute the bone marrow and help regenerate the blood and immune system.
Step 4: Engraftment: In this process, the patient is seeking comprehensive care with close monitoring to look for the sign of new stem cells take root – or “engraft” – in the bone marrow.
Step 5: Post Engraftment monitoring and continuation of immunosuppression