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Cytoreductive surgery and HIPEC Technology (Hyperthermic Intraperitoneal Chemotherapy)
Cancer in each of the abdominal organs can spread to abdominal surfaces and the peritoneum. This kind of spread is called peritoneal carcinomatosis and traditionally, considered an incurable disease. The life expectancy for patients with peritoneal carcinomatosis is very low - no more than several months.
Most cancers involving the peritoneum, originate from abdominal organs and include metastasis (spread) of cancer of the appendix, cancer of the colon and rectum, cancer of the ovaries, and cancer of the stomach. While primary cancers of the peritoneum are rare, they include peritoneal mesothelioma and primary peritoneal carcinoma. The term "Intraperitoneal" means that the treatment is delivered to the abdominal cavity. The term "Hyperthermic Chemotherapy" (HIPEC) means that the solution containing chemotherapy is heated to a temperature greater than normal body temperature. The administration of intra-peritoneal hyperthermic chemotherapy is called HIPEC.
Because heated chemotherapy can penetrate only at a very limited distance in the tumor tissue, it is imperative to remove all visible and palpable tumor deposits before HIPEC is delivered.
Surgery for removal of tumor deposits in the abdomen is known as cytoreductive surgery. Cytoreductive surgery is a complex surgical procedure, during which some organs are resected (removed). The average duration of surgery is between 6-11 hours. The abdomen is carefully inspected and all visible and palpable tumor deposits are removed and organs invaded by tumors are resected if there is no other choice. This type of complex surgery requires special equipment and surgical skills. After completion of the resection of all tumor tissue, the HIPEC procedure is performed.
During the HIPEC procedure, a machine will continuously circulate a heated sterile solution containing a chemotherapeutic agent throughout the peritoneal cavity, for one to one and half hours according to protocol. The HIPEC procedure is designed to attempt to kill any remaining cancer cells. The HIPEC procedure also improves drug absorption and effect with minimal exposure to the rest of the body. In this way, the normal side effects of chemotherapy can be avoided.
Most commonly treated diseases are pseudomyxoma peritonei, mesothelioma, colon and rectal cancer, appendiceal cancer, gastric cancer treatment, ovarian cancer, and primary peritoneal cancer.
Studies show that the HIPEC procedure, when combined with cytoreductive surgery, is an effective therapy that has improved survival outcomes for appropriately selected patients.
Contrary to the dismal results of conventional treatment of plain chemotherapy and standard surgery, this technique comes with a hope of prolonged survival and possible cure for select patients of Pseudomyxoma Peritonei from Mucinous Tumors of Appendix, Peritoneal Spread of Colorectal Cancer, Peritoneal Mesothelioma and Ovarian Cancer, Malignant Ascites.
BLK Cancer Centre in Delhi is amongst the first to offer HIPEC (Hyperthermic Intraperitoneal Chemotherapy) Technology in India. An acknowledged centre of excellence, BLK Cancer Centre is always adapting to new advancements in Oncology.
We are practicing Cytoreductive Surgery with HIPEC- An innovative procedure used to treat cancers that have originated in or spread to the abdominal cavity.
Dr. Kapil Kumar answers queries about cancer and its treatment...Read more
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